Enlarge / Minks are seen at a farm in Gjol, northern Denmark, on October 9, 2020. (credit: Getty | Henning Bagger )

Between September to January of this year, mink in three Polish farms tested positive for the pandemic coronavirus, SARS-CoV-2— presenting a concerning mystery as to how the animals became infected.

SARS-CoV-2 infections in mink aren't particularly noteworthy or concerning on their own; it's well established that mink are susceptible to the virus. The realization early in the pandemic resulted in extensive culls in Denmark and the Netherlands during 2020 and led to intensive monitoring and regulation of remaining mink herds in many places, including Poland.

But the recent cases in Polish mink , reported this week in the journal Eurosurveillance, are unusual. While previous mink outbreaks have linked to infected farmworkers and local circulation of the virus—indicating human-to-mink spread—none of the farm workers or families in the recently affected farms tested positive for the virus. In fact, health investigators found that the infected mink carried a strain of SARS-CoV-2 that has not been seen in humans in the region in more than two years (B.1.1.307).

Enlarge / Giant panda cub Huanlili plays with a bamboo during her first birthday at the Beauval zoological park in Saint-Aignan, central France, on August 2, 2022. (credit: Getty | GUILLAUME SOUVANT )

Chinese scientists have published their long-awaited genetic analysis of the samples and swabs they collected in early 2020 from the Huanan Seafood Market, the initial epicenter of the pandemic.

In the study , published Wednesday in Nature, the authors acknowledge for the first time that wildlife susceptible to SARS-CoV-2 infection—including raccoon dogs —were present in the market amid the plethora of genetic traces from SARS-CoV-2 and humans. But, the overall analysis is flawed, indicating the presence of animals that were almost certainly not at the market, including giant pandas, chimpanzees, and Atlantic grey seals. The authors continued to downplay the potential that a virus spillover from wildlife to humans in the crowded market was the spark that ignited the pandemic. Instead, they repeatedly put forward, without evidence, hypotheses favored by Chinese officials, namely that the virus was carried into the market via humans or frozen foods, and the bustling venue became an amplifier site for infection.

Still, the publication of the data is momentous—and a long time coming. Though the samples were collected from January 1 to March 30 of 2020, a draft of the study and some of the data were only first released in a preprint two years later, in February 2022. The preprint reported that SARS-CoV-2 was abundant amid human genetic material from the samples, indicating that the virus was prevalent among people at the market before it was shuttered on the morning of January 1. The authors, led by scientists at China's Centers for Disease Control and Prevention (China CDC), noted that they had also tested some animals in the market—mostly rabbits, stray cats, and snakes—but all were negative for SARS-CoV-2.

Enlarge / A person wearing a tinfoil hat on September 20, 2019. (credit: Getty | Bridget Bennett )

In the latest efforts by Republican lawmakers to enshrine into law Americans' right to freely spread deadly infectious diseases to each other, the Missouri House this week advanced a bill that would bar governments, schools, and employers from mandating certain vaccines—as well as things like vaccine microchips, which do not exist.

The bill, HB 700 ( PDF ), was sponsored by Rep. Bill Hardwick, a Republican from Waynesville. Hardwick told the St. Louis Post-Dispatch that he believed people " lost their minds " during the COVID-19 pandemic, and that legally barring officials and employers from requiring life-saving vaccination, even among health care workers, feels "like it's the right thing to do."

The bill specifically bars requirements for people to receive COVID-19 vaccines. But it doesn't stop there. It also bars any requirements for people to receive "a dose of messenger ribonucleic acid (mRNA)," thus barring requirements for any future mRNA-based vaccines, should they be needed in upcoming pandemics or outbreaks. It also bars requirements for "any treatment or procedure intended or designed to edit or alter human deoxyribonucleic acid (DNA) or the human genome," and "any mechanical or electronic device" that would be placed "under the skin."

Enlarge / Security guards stand in front of the closed Huanan Seafood Wholesale Market in the city of Wuhan, in the Hubei Province, on January 11, 2020, where the Wuhan health commission said that the man who died from a respiratory illness had purchased goods. (credit: Getty | NOEL CELIS )

A group of independent, international researchers has released its full analysis of newly uncovered metagenomic data collected by the Chinese Centers for Disease Control and Prevention in January and February of 2020. The data closely links SARS-CoV-2 to the genetic tracks of wild animals, particularly raccoon dogs , sold at the Huanan Wholesale Seafood Market in Wuhan, China, the early epicenter of the COVID-19 pandemic, the group's analysis says.

The full analysis provides additional, compelling evidence that the pandemic coronavirus made its leap to humans through a natural spillover, with a wild animal at the market acting as an intermediate host between the virus' natural reservoir in horseshoe bats and humans. It was authored by 19 scientists, led by Michael Worobey, an evolutionary biologist at the University of Arizona; Kristian Andersen, a virologist at the Scripps Research Institute in California; and Florence Débarre, a theoretician who specializes in evolutionary biology at France's national research agency, CNRS.

Prior to the release of the full analysis late Monday, information on the findings was only made public through media reports and statements from the World Health Organization, which was briefed on the analysis last week. But, the raw metagenomic data behind the analysis is still not publicly available. It was briefly posted on a public genetic database called the Global Initiative on Sharing Avian Influenza Data (GISAID) as recently as earlier this month, and the international researchers were able to download it during that window of availability. But, administrators for the database quickly removed the data after its discovery, saying the removal was at the request of the submitter, a researcher at China CDC.

Enlarge / The director of Germany's National Reference Centre for Invasive Fungal Infections holds a petri dish containing the yeast Candida auris in a laboratory at Wuerzburg University. (credit: Getty | Nicolas Armer )

A deadly, drug-resistant fungus emerging in the US gained ground faster and picked up yet more drug resistance amid the COVID-19 pandemic, researchers at the Centers for Disease Control and Prevention reported Monday.

The yeast Candida auris has been considered an "urgent threat"—the CDC's highest level of concern—since it was first reported in the US in 2016. The yeast lurks in health care settings and preys upon vulnerable patients, causing invasive infections with a fatality rate of between 30 to 60 percent.

In 2019, before the pandemic began, 17 states and Washington, DC, reported a total of 476 clinical cases. But in 2020, eight additional states reported cases for the first time, with the national clinical case count jumping 59 percent to 756. In 2021, 28 states were affected, with the clinical case count nearly doubling to 1,471. Asymptomatic cases detected through patient screening also jumped amid the pandemic, tripling from 1,310 cases in 2020 to 4,041 cases in 2021. The data appeared Monday in the Annals of Internal Medicine.

Enlarge / A raccoon dog at the Chapultpec Zoo in Mexico City on August 6, 2015. (credit: Getty | ALFREDO ESTRELLA/ )

Newly obtained genetic data from the Chinese Center for Disease Control and Prevention (China CDC) links the pandemic coronavirus SARS-CoV-2 to animals—specifically raccoon dogs—at the Huanan Seafood Wholesale Market in Wuhan, where the earliest COVID-19 cases centered, a group of independent scientists told the World Health Organization this week.

The genetic data came from environmental swabs collected at the market by China CDC in January of 2020. The existence of these swabs was previously known, as was the fact that they were positive for SARS-CoV-2 genetic material. But in late January of this year, scientists at China CDC uploaded—and then later removed—additional genetic data from these swabs to a public genetic database called GISAID, the WHO said. That additional data, which had not been previously disclosed, indicates that the SARS-CoV-2-positive swabs also contained genetic material from humans and animals, particularly large amounts of genetic material that closely matches that of raccoon dogs.

Raccoon dogs—foxlike animals whose faces closely resemble those of raccoons—are known to be susceptible to SARS-CoV-2 infection and were known to be sold at the market.

Enlarge / A microscope image of Streptococcus pyogenes , a common type of group A strep. (credit: Getty | BSIP )

In the wake of the COVID-19 pandemic and amid a tall wave of respiratory viruses, health officials in Colorado and Minnesota documented an unusual spike in deadly, invasive infections from Streptococcus bacteria late last year, according to a study published this week by the Centers for Disease Control and Prevention .

The spike is yet another oddity of post-pandemic disease transmission, but one that points to a simple prevention strategy: flu shots.

The infections are invasive group A strep , or iGAS for short, which is caused by the same group of bacteria that cause relatively minor diseases, such as strep throat and scarlet fever. But iGAS occurs when the bacteria spread in the body and cause severe infection, such as necrotizing fasciitis (flesh-eating disease), toxic shock syndrome, or sepsis. These conditions can occur quickly and be deadly.

Enlarge / WHO's COVID-19 technical lead, Maria Van Kerkhove, looks on during a press conference at the World Health Organization's headquarters in Geneva, on December 14, 2022. (credit: Getty | FABRICE COFFRINI )

While the World Health Organization says it's continuing to urge China to share data and cooperate with investigations into the origins of SARS-CoV-2, the United Nations' health agency is calling out another country for lack of transparency—the United States.

WHO officials on Friday said that the US has not shared reports or data from federal agencies that have assessed how the COVID-19 pandemic began. That includes the latest report by the Department of Energy , which determined with "low confidence" that the pandemic likely began due to a laboratory accident.

"As of right now, we don't have access to those reports or the data that is underlying how those reports were generated," Maria Van Kerkhove, WHO's technical lead on COVID-19, said in a press briefing Friday. "Again, we reiterate, that any agency that has information on this, it remains vital that that information is shared so that scientific debate, that this discussion, can move forward. Without that, we are not able to move forward in our understanding."

Enlarge / The Wuhan Institute of Virology in Wuhan in China's central Hubei province in February 2021 as members of the World Health Organization (WHO) team investigated the origins of the COVID-19 coronavirus. (credit: Getty | Hector Retamal )

The US Department of Energy has updated its previously undecided stance on the origin of the pandemic coronavirus, now saying with "low confidence" that it most likely emerged through a laboratory accident, according to a classified intelligence document first reported by The Wall Street Journal on Sunday .

The change reignites a bitter, often partisan debate over the elusive beginnings of SARS-CoV-2's global devastation, a debate which is largely fueled by insufficient evidence on both sides.

Still, the Energy Department is in the minority. Of the eight elements of the intelligence community that have reviewed information on the origin of SARS-CoV-2, only two currently lean toward the so-called "lab leak" hypothesis. The other is the Federal Bureau of Investigation, which concluded with "moderate confidence" in 2021 that the pandemic was ignited by a lab leak, according to the WSJ. It's unclear what evidence that assessment is based upon.