Enlarge / Security guards stand in front of the closed Huanan Seafood Wholesale Market in the city of Wuhan, in the Hubei Province, on January 11, 2020, where the Wuhan health commission said that the man who died from a respiratory illness had purchased goods. (credit: Getty | NOEL CELIS )

A group of independent, international researchers has released its full analysis of newly uncovered metagenomic data collected by the Chinese Centers for Disease Control and Prevention in January and February of 2020. The data closely links SARS-CoV-2 to the genetic tracks of wild animals, particularly raccoon dogs , sold at the Huanan Wholesale Seafood Market in Wuhan, China, the early epicenter of the COVID-19 pandemic, the group's analysis says.

The full analysis provides additional, compelling evidence that the pandemic coronavirus made its leap to humans through a natural spillover, with a wild animal at the market acting as an intermediate host between the virus' natural reservoir in horseshoe bats and humans. It was authored by 19 scientists, led by Michael Worobey, an evolutionary biologist at the University of Arizona; Kristian Andersen, a virologist at the Scripps Research Institute in California; and Florence Débarre, a theoretician who specializes in evolutionary biology at France's national research agency, CNRS.

Prior to the release of the full analysis late Monday, information on the findings was only made public through media reports and statements from the World Health Organization, which was briefed on the analysis last week. But, the raw metagenomic data behind the analysis is still not publicly available. It was briefly posted on a public genetic database called the Global Initiative on Sharing Avian Influenza Data (GISAID) as recently as earlier this month, and the international researchers were able to download it during that window of availability. But, administrators for the database quickly removed the data after its discovery, saying the removal was at the request of the submitter, a researcher at China CDC.

Enlarge / A raccoon dog at the Chapultpec Zoo in Mexico City on August 6, 2015. (credit: Getty | ALFREDO ESTRELLA/ )

Newly obtained genetic data from the Chinese Center for Disease Control and Prevention (China CDC) links the pandemic coronavirus SARS-CoV-2 to animals—specifically raccoon dogs—at the Huanan Seafood Wholesale Market in Wuhan, where the earliest COVID-19 cases centered, a group of independent scientists told the World Health Organization this week.

The genetic data came from environmental swabs collected at the market by China CDC in January of 2020. The existence of these swabs was previously known, as was the fact that they were positive for SARS-CoV-2 genetic material. But in late January of this year, scientists at China CDC uploaded—and then later removed—additional genetic data from these swabs to a public genetic database called GISAID, the WHO said. That additional data, which had not been previously disclosed, indicates that the SARS-CoV-2-positive swabs also contained genetic material from humans and animals, particularly large amounts of genetic material that closely matches that of raccoon dogs.

Raccoon dogs—foxlike animals whose faces closely resemble those of raccoons—are known to be susceptible to SARS-CoV-2 infection and were known to be sold at the market.

Enlarge / A microscope image of Streptococcus pyogenes , a common type of group A strep. (credit: Getty | BSIP )

In the wake of the COVID-19 pandemic and amid a tall wave of respiratory viruses, health officials in Colorado and Minnesota documented an unusual spike in deadly, invasive infections from Streptococcus bacteria late last year, according to a study published this week by the Centers for Disease Control and Prevention .

The spike is yet another oddity of post-pandemic disease transmission, but one that points to a simple prevention strategy: flu shots.

The infections are invasive group A strep , or iGAS for short, which is caused by the same group of bacteria that cause relatively minor diseases, such as strep throat and scarlet fever. But iGAS occurs when the bacteria spread in the body and cause severe infection, such as necrotizing fasciitis (flesh-eating disease), toxic shock syndrome, or sepsis. These conditions can occur quickly and be deadly.

Enlarge (credit: Getty | BSIP )

Surviving a bout of COVID-19 can significantly increase the risk of developing a range of long-term gastrointestinal symptoms and conditions—from constipation and diarrhea to chronic acid reflux, pancreatitis, and inflammation of the bile ducts—according to a study published this week in Nature Communications .

The study likely confirms what many long COVID patients already know all too well. But the analysis is among the largest and most comprehensive to evaluate the boost in relative and absolute risks, drawing on medical records from more than 11,652,484 people in the Department of Veterans Affairs databases.

The study was led by clinical epidemiologist Ziyad Al-Aly at the VA Saint Louis Health Care System in Saint Louis. With colleagues, Al-Aly examined medical records of over 154,000 people who had COVID-19 between March 2020 and January 2021. The researchers then compared the COVID survivors' rates of gastrointestinal problems in the year after their infection to the rates seen in two control cohorts. One was a contemporary cohort of over 5.6 million people who went from the March 2020 to January 2021 without any evidence of a COVID-19 infection. The other was of 5.8 million people who were tracked for a year before the pandemic, which served as a control for unreported COVID-19 cases in the contemporary cohort.

Enlarge / WHO's COVID-19 technical lead, Maria Van Kerkhove, looks on during a press conference at the World Health Organization's headquarters in Geneva, on December 14, 2022. (credit: Getty | FABRICE COFFRINI )

While the World Health Organization says it's continuing to urge China to share data and cooperate with investigations into the origins of SARS-CoV-2, the United Nations' health agency is calling out another country for lack of transparency—the United States.

WHO officials on Friday said that the US has not shared reports or data from federal agencies that have assessed how the COVID-19 pandemic began. That includes the latest report by the Department of Energy , which determined with "low confidence" that the pandemic likely began due to a laboratory accident.

"As of right now, we don't have access to those reports or the data that is underlying how those reports were generated," Maria Van Kerkhove, WHO's technical lead on COVID-19, said in a press briefing Friday. "Again, we reiterate, that any agency that has information on this, it remains vital that that information is shared so that scientific debate, that this discussion, can move forward. Without that, we are not able to move forward in our understanding."

Enlarge / The Wuhan Institute of Virology in Wuhan in China's central Hubei province in February 2021 as members of the World Health Organization (WHO) team investigated the origins of the COVID-19 coronavirus. (credit: Getty | Hector Retamal )

The US Department of Energy has updated its previously undecided stance on the origin of the pandemic coronavirus, now saying with "low confidence" that it most likely emerged through a laboratory accident, according to a classified intelligence document first reported by The Wall Street Journal on Sunday .

The change reignites a bitter, often partisan debate over the elusive beginnings of SARS-CoV-2's global devastation, a debate which is largely fueled by insufficient evidence on both sides.

Still, the Energy Department is in the minority. Of the eight elements of the intelligence community that have reviewed information on the origin of SARS-CoV-2, only two currently lean toward the so-called "lab leak" hypothesis. The other is the Federal Bureau of Investigation, which concluded with "moderate confidence" in 2021 that the pandemic was ignited by a lab leak, according to the WSJ. It's unclear what evidence that assessment is based upon.

Enlarge / Passengers on an Air France flight on April 20, 2021. (credit: Getty | Francois LOCHON )

In a small trial, aircraft wastewater proved easy and useful for monitoring the SARS-CoV-2 variants touching down in the US, the Centers for Disease Control and Prevention reported Thursday.

The study found that the testing could be done cheaply and easily; it only added about three extra minutes to aircraft maintenance times at airports and didn't require hassling passengers with nose swabs or other sampling methods. Moreover, the testing could be easily scaled up as needed as the world largely abandons other SARS-CoV-2 testing and monitoring strategies, the CDC authors concluded.

"This investigation demonstrated the feasibility of aircraft wastewater surveillance as a low-resource approach compared with individual testing to monitor SARS-CoV-2 variants without direct traveler involvement or disruption to airport operations," the authors concluded.

Enlarge / World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus. (credit: Getty | Fabrice Cof )

The World Health Organization on Monday renewed its declaration that the COVID-19 pandemic constitutes a public health emergency of international concern (PHEIC)—the agency's highest level of alert—but acknowledged that the 3-year-old crisis may be nearing an "inflection point," after which the virus could be downgraded to a less dire but permanent fixture in the gamut of human pathogens.

On Friday, the agency convened its emergency committee for the 14th time to assess the global status of the pandemic coronavirus. The week marked the three-year anniversary of the agency's initial COVID-19 PHEIC declaration.

"As we enter the fourth year of the pandemic, we are certainly in a much better position now than we were a year ago, when the omicron wave was at its peak, and more than 70,000 deaths were being reported to WHO each week," WHO Director-General Dr. Tedros Adhanom Ghebreyesus said in opening remarks to Friday's committee meeting.

Enlarge / Dr. Peter Marks, director of the Center for Biologics Evaluation and Research within the Food and Drug Administration, testifies during a Senate Health, Education, Labor, and Pensions Committee hearing on the federal coronavirus response on Capitol Hill in March 2021, in Washington, DC. (credit: Getty | Pool )

The US Food and Drug Administration's committee of independent vaccine experts gathered Thursday to discuss the future of COVID-19 shots. The meeting seemed primed for explosive debate. Earlier in the week, the FDA released documents that made clear the agency is holding steadfast to its idea that COVID vaccines will fit the mold of annual flu shots —with reformulations decided in the first half of each year, followed by fall rollouts in anticipation of winter waves.

But outside experts, including some on the FDA's advisory committee, have questioned almost every aspect of that plan—from the uncertain seasonality of COVID-19 so far, to the futility of chasing fast-moving variants (or subvariants, as the case may be). Some have even questioned whether there's a need to boost the young and healthy so frequently when current vaccines offer protection against severe disease, but only short-lived protection against infection.

One particularly outspoken member of FDA's committee, Paul Offit, a pediatrician and infectious disease expert at Children’s Hospital of Philadelphia, has publicly assailed the bivalent booster, writing a commentary piece in the New England Journal of Medicine earlier this month titled: Bivalent Covid-19 Vaccines — A Cautionary Tale . (The FDA's advisory committee voted 19-2 in support of the bivalent boosters last year, with Offit being one of the two votes against.)